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Hydrogen-rich saline ameliorates the retina against light-induced damage in rats

Overview of attention for article published in Medical Gas Research, September 2013
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Title
Hydrogen-rich saline ameliorates the retina against light-induced damage in rats
Published in
Medical Gas Research, September 2013
DOI 10.1186/2045-9912-3-19
Pubmed ID
Authors

Liang Tian, Lei Zhang, Feng Xia, Jing An, Yashino Sugita, Zuoming Zhang

Abstract

Oxidative reactions are thought to be a major cause of light-induced retinal degeneration. This study was designed to investigate the effects of hydrogen-rich saline (HRS) on the prevention and treatment of light-induced retinal injury in rats. Male Sprague-Dawley rats were divided randomly into three groups: light damage, HRS prevention (5 ml/kg, 30 min before intensive light exposure), and HRS treatment (5 ml/kg per day for 5 days, after intensive light exposure), respectively. The right eye of each rat was exposed to 5000 lux constant white light-emitting diode (LED) light for 3 h, and the left eye was covered to serve as the blank control. Electroretinograms were recorded 5 days later, and the thickness of the outer nuclear layer (ONL) was measured after hematoxylin and eosin (H&E) staining. The results showed that the electroretinogram b-wave amplitudes and the mean ONL thicknesses of rats were significantly greater in the HRS prevention (P < 0.001) and treatment (P < 0.001) groups than in the light damage. These results indicated that peritoneal injection of HRS provides protection and treatment against light-induced retinal degeneration in rats.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 24%
Student > Doctoral Student 3 14%
Researcher 3 14%
Student > Bachelor 1 5%
Professor 1 5%
Other 4 19%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 9 43%
Biochemistry, Genetics and Molecular Biology 2 10%
Veterinary Science and Veterinary Medicine 1 5%
Agricultural and Biological Sciences 1 5%
Chemical Engineering 1 5%
Other 2 10%
Unknown 5 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2015.
All research outputs
#20,200,843
of 22,719,618 outputs
Outputs from Medical Gas Research
#324
of 333 outputs
Outputs of similar age
#175,675
of 200,186 outputs
Outputs of similar age from Medical Gas Research
#2
of 2 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 333 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,186 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.