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Anticonvulsant activity of bone marrow cells in electroconvulsive seizures in mice

Overview of attention for article published in BMC Neuroscience, September 2013
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Title
Anticonvulsant activity of bone marrow cells in electroconvulsive seizures in mice
Published in
BMC Neuroscience, September 2013
DOI 10.1186/1471-2202-14-97
Pubmed ID
Authors

Enéas Galdini Ferrazoli, Miriam Marcela Blanco, Simone Bittencourt, André Luis Lacerda Bachi, Luciana Bahia, Milena Botelho Pereira Soares, Ricardo Ribeiro-dos-Santos, Luiz Eugênio Mello, Beatriz Monteiro Longo

Abstract

Bone marrow is an accessible source of progenitor cells, which have been investigated as treatment for neurological diseases in a number of clinical trials. Here we evaluated the potential benefit of bone marrow cells in protecting against convulsive seizures induced by maximum electroconvulsive shock (MES), a widely used model for screening of anti-epileptic drugs. Behavioral and inflammatory responses were measured after MES induction in order to verify the effects promoted by transplantation of bone marrow cells. To assess the anticonvulsant effects of bone marrow cell transplantation, we measured the frequency and duration of tonic seizure, the mortality rate, the microglial expression and the blood levels of cytokine IL-1, IL-6, IL-10 and TNF-α after MES induction. We hypothesized that these behavioral and inflammatory responses to a strong stimulus such as a convulsive seizure could be modified by the transplantation of bone marrow cells.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Ph. D. Student 5 17%
Other 4 14%
Student > Master 3 10%
Professor 2 7%
Other 4 14%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 11 38%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Neuroscience 3 10%
Immunology and Microbiology 1 3%
Other 2 7%
Unknown 5 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2013.
All research outputs
#20,200,843
of 22,719,618 outputs
Outputs from BMC Neuroscience
#1,052
of 1,241 outputs
Outputs of similar age
#172,513
of 197,012 outputs
Outputs of similar age from BMC Neuroscience
#34
of 50 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,241 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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