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Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen

Overview of attention for article published in BMC Gastroenterology, September 2013
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1 X user
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1 Facebook page

Citations

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25 Dimensions

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28 Mendeley
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Title
Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen
Published in
BMC Gastroenterology, September 2013
DOI 10.1186/1471-230x-13-135
Pubmed ID
Authors

Elizabeth A Mann, Eleana Harmel-Laws, Mitchell B Cohen, Kris A Steinbrecher

Abstract

Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates intracellular cGMP and is implicated in intestinal ion secretion, cell proliferation, apoptosis, intestinal barrier function, as well as the susceptibility of the intestine to inflammation. Our aim was to determine if GC-C is required for host defense during infection by the murine enteric pathogen Citrobacter rodentium of the family Enterobacteriacea.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 39%
Student > Master 4 14%
Student > Bachelor 3 11%
Professor 3 11%
Professor > Associate Professor 2 7%
Other 2 7%
Unknown 3 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 29%
Agricultural and Biological Sciences 8 29%
Medicine and Dentistry 4 14%
Immunology and Microbiology 2 7%
Social Sciences 1 4%
Other 1 4%
Unknown 4 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2013.
All research outputs
#17,695,202
of 22,719,618 outputs
Outputs from BMC Gastroenterology
#1,042
of 1,732 outputs
Outputs of similar age
#142,042
of 198,170 outputs
Outputs of similar age from BMC Gastroenterology
#9
of 16 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,732 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,170 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.