Title |
Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules
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Published in |
BMC Genomics, November 2011
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DOI | 10.1186/1471-2164-12-578 |
Pubmed ID | |
Authors |
Marc S Halfon, Qianqian Zhu, Elizabeth R Brennan, Yiyun Zhou |
Abstract |
Cis-regulatory modules are bound by transcription factors to regulate gene expression. Characterizing these DNA sequences is central to understanding gene regulatory networks and gaining insight into mechanisms of transcriptional regulation, but genome-scale regulatory module discovery remains a challenge. One popular approach is to scan the genome for clusters of transcription factor binding sites, especially those conserved in related species. When such approaches are successful, it is typically assumed that the activity of the modules is mediated by the identified binding sites and their cognate transcription factors. However, the validity of this assumption is often not assessed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 2 | 4% |
United States | 2 | 4% |
United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Unknown | 40 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 39% |
Student > Ph. D. Student | 7 | 15% |
Professor > Associate Professor | 6 | 13% |
Professor | 4 | 9% |
Student > Master | 3 | 7% |
Other | 2 | 4% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 59% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Computer Science | 1 | 2% |
Physics and Astronomy | 1 | 2% |
Neuroscience | 1 | 2% |
Other | 0 | 0% |
Unknown | 9 | 20% |