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Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules

Overview of attention for article published in BMC Genomics, November 2011
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Citations

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Title
Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules
Published in
BMC Genomics, November 2011
DOI 10.1186/1471-2164-12-578
Pubmed ID
Authors

Marc S Halfon, Qianqian Zhu, Elizabeth R Brennan, Yiyun Zhou

Abstract

Cis-regulatory modules are bound by transcription factors to regulate gene expression. Characterizing these DNA sequences is central to understanding gene regulatory networks and gaining insight into mechanisms of transcriptional regulation, but genome-scale regulatory module discovery remains a challenge. One popular approach is to scan the genome for clusters of transcription factor binding sites, especially those conserved in related species. When such approaches are successful, it is typically assumed that the activity of the modules is mediated by the identified binding sites and their cognate transcription factors. However, the validity of this assumption is often not assessed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 4%
United States 2 4%
United Kingdom 1 2%
Spain 1 2%
Unknown 41 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 38%
Student > Ph. D. Student 7 15%
Professor > Associate Professor 6 13%
Professor 4 9%
Student > Master 3 6%
Other 3 6%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 57%
Biochemistry, Genetics and Molecular Biology 7 15%
Computer Science 1 2%
Physics and Astronomy 1 2%
Neuroscience 1 2%
Other 0 0%
Unknown 10 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2013.
All research outputs
#9,906,295
of 12,373,620 outputs
Outputs from BMC Genomics
#5,684
of 7,296 outputs
Outputs of similar age
#106,116
of 155,323 outputs
Outputs of similar age from BMC Genomics
#30
of 44 outputs
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So far Altmetric has tracked 7,296 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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