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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study
|
|---|---|
| Published in |
Stem Cell Research & Therapy, March 2017
|
| DOI | 10.1186/s13287-017-0506-5 |
| Pubmed ID | |
| Authors |
Misako Nakashima, Koichiro Iohara, Masashi Murakami, Hiroshi Nakamura, Yayoi Sato, Yoshiko Ariji, Kenji Matsushita |
| Abstract |
Experiments have previously demonstrated the therapeutic potential of mobilized dental pulp stem cells (MDPSCs) for complete pulp regeneration. The aim of the present pilot clinical study is to assess the safety, potential efficacy, and feasibility of autologous transplantation of MDPSCs in pulpectomized teeth. Five patients with irreversible pulpitis were enrolled and monitored for up to 24 weeks following MDPSC transplantation. The MDPSCs were isolated from discarded teeth and expanded based on good manufacturing practice (GMP). The quality of the MDPSCs at passages 9 or 10 was ascertained by karyotype analyses. The MDPSCs were transplanted with granulocyte colony-stimulating factor (G-CSF) in atelocollagen into pulpectomized teeth. The clinical and laboratory evaluations demonstrated no adverse events or toxicity. The electric pulp test (EPT) of the pulp at 4 weeks demonstrated a robust positive response. The signal intensity of magnetic resonance imaging (MRI) of the regenerated tissue in the root canal after 24 weeks was similar to that of normal dental pulp in the untreated control. Finally, cone beam computed tomography demonstrated functional dentin formation in three of the five patients. Human MDPSCs are safe and efficacious for complete pulp regeneration in humans in this pilot clinical study. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 20% |
| United States | 1 | 10% |
| Mexico | 1 | 10% |
| Saudi Arabia | 1 | 10% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Scientists | 3 | 30% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 338 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 337 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 38 | 11% |
| Student > Bachelor | 38 | 11% |
| Student > Ph. D. Student | 28 | 8% |
| Student > Doctoral Student | 22 | 7% |
| Student > Postgraduate | 20 | 6% |
| Other | 56 | 17% |
| Unknown | 136 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 141 | 42% |
| Biochemistry, Genetics and Molecular Biology | 22 | 7% |
| Agricultural and Biological Sciences | 8 | 2% |
| Materials Science | 4 | 1% |
| Neuroscience | 3 | <1% |
| Other | 14 | 4% |
| Unknown | 146 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2022.
All research outputs
#2,502,079
of 24,707,218 outputs
Outputs from Stem Cell Research & Therapy
#177
of 2,655 outputs
Outputs of similar age
#46,208
of 312,662 outputs
Outputs of similar age from Stem Cell Research & Therapy
#5
of 59 outputs
Altmetric has tracked 24,707,218 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,655 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.