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Translational HIV-1 research: from routine diagnostics to new virology insights in Amsterdam, the Netherlands during 1983-2013

Overview of attention for article published in Retrovirology, August 2013
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Title
Translational HIV-1 research: from routine diagnostics to new virology insights in Amsterdam, the Netherlands during 1983-2013
Published in
Retrovirology, August 2013
DOI 10.1186/1742-4690-10-93
Pubmed ID
Authors

Antoinette C van der Kuyl, Margreet Bakker, Suzanne Jurriaans, Nicole KT Back, Alexander O Pasternak, Marion Cornelissen, Ben Berkhout

Abstract

An HIV-1 diagnostic laboratory was established in the Academic Medical Center (AMC) of the University of Amsterdam after the discovery of human immunodeficiency virus (HIV) as the cause of the acquired immunodeficiency syndrome (AIDS). The first AIDS patients were diagnosed here in 1981 and since 1983 we have tested the samples of 50992 patients using a variety of assays that greatly improved over the years. We will describe some of the basic results from this diagnostic laboratory and then focus on the spin-off in terms of the development of novel virus assays to detect super-infections and ultra-sensitive assays to measure the intracellular HIV-1 RNA load. We also review several original research findings in the field of HIV-1 virology that stem from initial observations made in the diagnostic unit. This includes the study of genetic defects in the HIV-1 genome and time trends of the replication fitness over 30 years of viral evolution, but also the description of novel HIV-1 variants in difficult-to-diagnose clinical specimen.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Cameroon 1 4%
United States 1 4%
Unknown 22 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 21%
Researcher 5 21%
Student > Doctoral Student 2 8%
Student > Postgraduate 2 8%
Professor 2 8%
Other 5 21%
Unknown 3 13%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Agricultural and Biological Sciences 4 17%
Biochemistry, Genetics and Molecular Biology 2 8%
Social Sciences 2 8%
Immunology and Microbiology 2 8%
Other 4 17%
Unknown 3 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2013.
All research outputs
#18,347,414
of 22,721,584 outputs
Outputs from Retrovirology
#955
of 1,104 outputs
Outputs of similar age
#149,475
of 200,084 outputs
Outputs of similar age from Retrovirology
#14
of 17 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,104 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,084 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.