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Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis

Overview of attention for article published in Orphanet Journal of Rare Diseases, September 2013
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Title
Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis
Published in
Orphanet Journal of Rare Diseases, September 2013
DOI 10.1186/1750-1172-8-133
Pubmed ID
Authors

Martijn J de Groot, Marieke Hoeksma, Dirk-Jan Reijngoud, Harold W de Valk, Anne MJ Paans, Pieter JJ Sauer, Francjan J van Spronsen

Abstract

In phenylketonuria (PKU), elevated blood phenylalanine (Phe) concentrations are considered to impair transport of large neutral amino acids (LNAAs) from blood to brain. This impairment is believed to underlie cognitive deficits in PKU via different mechanisms, including reduced cerebral protein synthesis. In this study, we investigated the hypothesis that impaired LNAA influx relates to reduced cerebral protein synthesis.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 21%
Student > Master 8 14%
Researcher 7 12%
Student > Ph. D. Student 5 9%
Student > Doctoral Student 4 7%
Other 8 14%
Unknown 14 24%
Readers by discipline Count As %
Medicine and Dentistry 13 22%
Biochemistry, Genetics and Molecular Biology 8 14%
Psychology 5 9%
Neuroscience 5 9%
Agricultural and Biological Sciences 3 5%
Other 7 12%
Unknown 17 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2013.
All research outputs
#15,279,577
of 22,721,584 outputs
Outputs from Orphanet Journal of Rare Diseases
#1,778
of 2,604 outputs
Outputs of similar age
#120,977
of 196,876 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#24
of 34 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,876 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.