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Rapamycin increases survival in ALS mice lacking mature lymphocytes

Overview of attention for article published in Molecular Neurodegeneration, September 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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Citations

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84 Mendeley
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Title
Rapamycin increases survival in ALS mice lacking mature lymphocytes
Published in
Molecular Neurodegeneration, September 2013
DOI 10.1186/1750-1326-8-31
Pubmed ID
Authors

Kim A Staats, Sara Hernandez, Susann Schönefeldt, André Bento-Abreu, James Dooley, Philip Van Damme, Adrian Liston, Wim Robberecht, Ludo Van Den Bosch

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. Disease pathophysiology is complex and not yet fully understood, but is proposed to include the accumulation of misfolded proteins, as aggregates are present in spinal cords from ALS patients and in ALS model organisms. Increasing autophagy is hypothesized to be protective in ALS as it removes these aggregates. Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Turkey 1 1%
France 1 1%
Belgium 1 1%
Unknown 80 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 19%
Student > Master 11 13%
Student > Bachelor 10 12%
Student > Doctoral Student 9 11%
Researcher 8 10%
Other 8 10%
Unknown 22 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 30%
Neuroscience 11 13%
Biochemistry, Genetics and Molecular Biology 9 11%
Medicine and Dentistry 6 7%
Immunology and Microbiology 3 4%
Other 8 10%
Unknown 22 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2013.
All research outputs
#6,183,737
of 22,721,584 outputs
Outputs from Molecular Neurodegeneration
#561
of 845 outputs
Outputs of similar age
#53,673
of 198,457 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 9 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 845 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,457 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.