Title |
Rapamycin increases survival in ALS mice lacking mature lymphocytes
|
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Published in |
Molecular Neurodegeneration, September 2013
|
DOI | 10.1186/1750-1326-8-31 |
Pubmed ID | |
Authors |
Kim A Staats, Sara Hernandez, Susann Schönefeldt, André Bento-Abreu, James Dooley, Philip Van Damme, Adrian Liston, Wim Robberecht, Ludo Van Den Bosch |
Abstract |
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. Disease pathophysiology is complex and not yet fully understood, but is proposed to include the accumulation of misfolded proteins, as aggregates are present in spinal cords from ALS patients and in ALS model organisms. Increasing autophagy is hypothesized to be protective in ALS as it removes these aggregates. Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated. |
X Demographics
Geographical breakdown
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Ghana | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 1% |
Turkey | 1 | 1% |
France | 1 | 1% |
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Unknown | 80 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 13% |
Student > Bachelor | 10 | 12% |
Student > Doctoral Student | 9 | 11% |
Researcher | 8 | 10% |
Other | 8 | 10% |
Unknown | 22 | 26% |
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Immunology and Microbiology | 3 | 4% |
Other | 8 | 10% |
Unknown | 22 | 26% |