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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

Overview of attention for article published in Malaria Journal, September 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)

Mentioned by

twitter
13 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page
video
1 video uploader

Citations

dimensions_citation
60 Dimensions

Readers on

mendeley
247 Mendeley
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Title
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
Published in
Malaria Journal, September 2013
DOI 10.1186/1475-2875-12-317
Pubmed ID
Authors

Lauren Gong, Sunil Parikh, Philip J Rosenthal, Bryan Greenhouse

Abstract

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Colombia 1 <1%
Burkina Faso 1 <1%
Portugal 1 <1%
India 1 <1%
Italy 1 <1%
Nigeria 1 <1%
Canada 1 <1%
Unknown 238 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 57 23%
Student > Master 44 18%
Student > Ph. D. Student 34 14%
Student > Postgraduate 22 9%
Researcher 18 7%
Other 46 19%
Unknown 26 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 60 24%
Medicine and Dentistry 60 24%
Biochemistry, Genetics and Molecular Biology 45 18%
Immunology and Microbiology 11 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 34 14%
Unknown 32 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2021.
All research outputs
#2,155,126
of 21,022,292 outputs
Outputs from Malaria Journal
#481
of 5,288 outputs
Outputs of similar age
#19,901
of 179,859 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 21,022,292 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,288 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,859 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them