Title |
Experience-dependent persistent expression of zif268during rest is preserved in the aged dentate gyrus
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Published in |
BMC Neuroscience, September 2013
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DOI | 10.1186/1471-2202-14-100 |
Pubmed ID | |
Authors |
Ali Gheidi, Erin Azzopardi, Allison A Adams, Diano F Marrone |
Abstract |
Aging is typically accompanied by memory decline and changes in hippocampal function. Among these changes is a decline in the activity of the dentate gyrus (DG) during behavior. Lasting memory, however, is thought to also require recapitulation of recent memory traces during subsequent rest - a phenomenon, termed memory trace reactivation, which is compromised in hippocampal CA1 with progressive age. This process has yet to be assessed in the aged DG, despite its prominent role in age-related memory impairment. Using zif268 transcription to measure granule cell recruitment, DG activity in adult and aged animals was assessed both during spatial exploration and as animals remained at rest in the home cage in order to detect potential memory-related replay. |
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