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Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Overview of attention for article published in Arthritis Research & Therapy, January 2012
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1 Redditor

Citations

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319 Mendeley
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Title
Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4
Published in
Arthritis Research & Therapy, January 2012
DOI 10.1186/ar3555
Pubmed ID
Authors

Dong Hyun Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson

Abstract

Osteoarthritis (OA) is a degenerative disease characterized by cartilage breakdown in the synovial joints. The presence of low-grade inflammation in OA joints is receiving increasing attention, with synovitis shown to be present even in the early stages of the disease. How the synovial inflammation arises is unclear, but proteins in the synovial fluid of affected joints could conceivably contribute. We therefore surveyed the proteins present in OA synovial fluid and assessed their immunostimulatory properties.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 319 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Spain 1 <1%
Denmark 1 <1%
Germany 1 <1%
Unknown 314 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 59 18%
Student > Ph. D. Student 53 17%
Student > Master 42 13%
Student > Bachelor 28 9%
Student > Doctoral Student 21 7%
Other 46 14%
Unknown 70 22%
Readers by discipline Count As %
Medicine and Dentistry 72 23%
Agricultural and Biological Sciences 46 14%
Biochemistry, Genetics and Molecular Biology 45 14%
Engineering 15 5%
Pharmacology, Toxicology and Pharmaceutical Science 12 4%
Other 43 13%
Unknown 86 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2013.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#3,132
of 3,381 outputs
Outputs of similar age
#225,910
of 247,455 outputs
Outputs of similar age from Arthritis Research & Therapy
#51
of 53 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,455 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.