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The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded

Overview of attention for article published in Cardiovascular Diabetology, June 2005
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Title
The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded
Published in
Cardiovascular Diabetology, June 2005
DOI 10.1186/1475-2840-4-9
Pubmed ID
Authors

Melvin R Hayden, James R Sowers, Suresh C Tyagi

Abstract

The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active polymer. These matrices provide a gel-like form and scaffolding structure with regional tensile strength provided by collagens, elasticity by elastins, adhesiveness by structural glycoproteins, compressibility by proteoglycans--hyaluronans, and communicability by a family of integrins, which exchanges information between cells and between cells and the extracellular matrix of vascular tissues. Each component of the extracellular matrix and specifically the capillary basement membrane possesses unique structural properties and interactions with one another, which determine the separate and combined roles in the multiple diabetic complications or diabetic opathies. Metabolic syndrome, prediabetes, type 2 diabetes mellitus, and their parallel companion (atheroscleropathy) are associated with multiple metabolic toxicities and chronic injurious stimuli. The adaptable quality of a matrix or form genetically preloaded with the necessary information to communicate and respond to an ever-changing environment, which supports the interstitium, capillary and arterial vessel wall is individually examined.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 2 2%
United States 2 2%
Switzerland 1 1%
Unknown 88 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 28%
Student > Master 14 15%
Researcher 12 13%
Professor > Associate Professor 11 12%
Student > Doctoral Student 6 6%
Other 11 12%
Unknown 13 14%
Readers by discipline Count As %
Medicine and Dentistry 26 28%
Biochemistry, Genetics and Molecular Biology 18 19%
Agricultural and Biological Sciences 17 18%
Engineering 3 3%
Neuroscience 3 3%
Other 8 9%
Unknown 18 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2013.
All research outputs
#20,202,510
of 22,721,584 outputs
Outputs from Cardiovascular Diabetology
#1,202
of 1,366 outputs
Outputs of similar age
#55,018
of 56,633 outputs
Outputs of similar age from Cardiovascular Diabetology
#2
of 2 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,366 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 56,633 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.