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Influenza virus antigenic variation, host antibody production and new approach to control epidemics

Overview of attention for article published in Virology Journal, March 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

patent
2 patents
wikipedia
6 Wikipedia pages

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
130 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
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Title
Influenza virus antigenic variation, host antibody production and new approach to control epidemics
Published in
Virology Journal, March 2009
DOI 10.1186/1743-422x-6-30
Pubmed ID
Authors

Jiezhong Chen, Yi-Mo Deng

Abstract

Influenza is an infectious disease and can lead to life-threatening complications like pneumonia. The disease is caused by three types of RNA viruses called influenza types A, B and C, each consisting of eight negative single-stranded RNA-segments encoding 11 proteins. Current annual vaccines contain two type A strains and one type B strain and are capable of inducing strong antibody responses to both the surface glycoprotein hemagglutinin and the neuraminidase. While these vaccines are protective against vaccine viruses they are not effective against newly emerging viruses that contain antigenic variations known as antigenic drift and shift. In nature, environmental selection pressure generally plays a key role in selecting antigenic changes in the antigen determining spots of hemagglutinin, resulting in changes in the antigenicity of the virus. Recently, a new technology has been developed where influenza-specific IgG+ antibody-secreting plasma cells can be isolated and cloned directly from vaccinated humans and high affinity monoclonal antibodies can be produced within several weeks after vaccination. The new technology holds great promise for the development of effective passive antibody therapy to limit the spread of influenza viruses in a timely manner.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Mexico 1 <1%
United States 1 <1%
Unknown 127 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 38 29%
Student > Ph. D. Student 22 17%
Researcher 19 15%
Student > Master 17 13%
Student > Doctoral Student 5 4%
Other 11 8%
Unknown 18 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 35%
Immunology and Microbiology 19 15%
Biochemistry, Genetics and Molecular Biology 13 10%
Medicine and Dentistry 9 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 16 12%
Unknown 22 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2021.
All research outputs
#3,798,611
of 25,373,627 outputs
Outputs from Virology Journal
#397
of 3,391 outputs
Outputs of similar age
#13,039
of 109,697 outputs
Outputs of similar age from Virology Journal
#3
of 11 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,391 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,697 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.