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Molecules in pain and sex: a developing story

Overview of attention for article published in Molecular Brain, March 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
3 X users
facebook
1 Facebook page

Citations

dimensions_citation
77 Dimensions

Readers on

mendeley
129 Mendeley
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Title
Molecules in pain and sex: a developing story
Published in
Molecular Brain, March 2017
DOI 10.1186/s13041-017-0289-8
Pubmed ID
Authors

Josiane C. S. Mapplebeck, Simon Beggs, Michael W. Salter

Abstract

Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Peripheral nerve injury, a common cause of neuropathic pain, engages microglia-neuronal signalling which causes disinhibition and facilitated excitation of spinal nociceptive pathways. However, recent literature indicates that the role of microglia in neuropathic pain is sexually dimorphic, and that female pain processing appears to be independent of microglia, depending rather on T cells. Despite this sex difference, pain signalling in the spinal cord converges downstream of microglia, as NMDAR-mediated facilitated excitation in pain transmitting neurons is consistent between males and females. Determining whether pain signalling is sexually dimorphic in humans and, further, addressing the sex bias in pain research will increase the translational relevance of preclinical findings and advance our understanding of chronic pain in women.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 129 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 16%
Student > Bachelor 20 16%
Student > Master 16 12%
Researcher 14 11%
Student > Doctoral Student 10 8%
Other 26 20%
Unknown 22 17%
Readers by discipline Count As %
Neuroscience 42 33%
Medicine and Dentistry 19 15%
Agricultural and Biological Sciences 14 11%
Biochemistry, Genetics and Molecular Biology 9 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Other 13 10%
Unknown 29 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2022.
All research outputs
#3,634,729
of 22,959,818 outputs
Outputs from Molecular Brain
#217
of 1,117 outputs
Outputs of similar age
#65,607
of 307,998 outputs
Outputs of similar age from Molecular Brain
#5
of 11 outputs
Altmetric has tracked 22,959,818 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,117 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,998 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.