Title |
YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
|
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Published in |
Journal of Translational Medicine, September 2013
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DOI | 10.1186/1479-5876-11-216 |
Pubmed ID | |
Authors |
Klaus Mantwill, Ulrike Naumann, Janina Seznec, Vroni Girbinger, Hermann Lage, Pawel Surowiak, Dagmar Beier, Michel Mittelbronn, Jürgen Schlegel, Per Sonne Holm |
Abstract |
The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence. In brain CSC, the PI3-K/AKT and the RAS/mitogen activated protein kinase (MAPK) pathways are found to be activated. In consequence, the human transcription factor YB-1, knowing to be responsible for the emergence of drug resistance and driving adenoviral replication, is phosphorylated and activated. With this knowledge, YB-1 was established in the past as a biomarker for disease progression and prognosis. This study determines the expression of YB-1 in glioblastoma (GBM) specimen in vivo and in brain CSC lines. In addition, the capacity of Ad-Delo3-RGD, an YB-1 dependent oncolytic adenovirus, to eradicate CSC was evaluated both in vitro and in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 20% |
Canada | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 19% |
Researcher | 7 | 13% |
Student > Master | 7 | 13% |
Student > Ph. D. Student | 5 | 10% |
Lecturer | 3 | 6% |
Other | 5 | 10% |
Unknown | 15 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 21% |
Agricultural and Biological Sciences | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Psychology | 3 | 6% |
Neuroscience | 3 | 6% |
Other | 3 | 6% |
Unknown | 17 | 33% |