Title |
Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy
|
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Published in |
Journal of Neuroinflammation, September 2013
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DOI | 10.1186/1742-2094-10-110 |
Pubmed ID | |
Authors |
Alexandre Savard, Karine Lavoie, Marie-Elsa Brochu, Djordje Grbic, Martin Lepage, Denis Gris, Guillaume Sebire |
Abstract |
Infection-inflammation combined with hypoxia-ischemia (HI) is the most prevalent pathological scenario involved in perinatal brain damage leading to life-long neurological disabilities. Following lipopolysaccharide (LPS) and/or HI aggression, different patterns of inflammatory responses have been uncovered according to the brain differentiation stage. In fact, LPS pre-exposure has been reported to aggravate HI brain lesions in post-natal day 1 (P1) and P7 rat models that are respectively equivalent - in terms of brain development - to early and late human preterm newborns. However, little is known about the innate immune response in LPS plus HI-induced lesions of the full-term newborn forebrain and the associated neuropathological and neurobehavioral outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 29% |
Researcher | 9 | 15% |
Student > Master | 7 | 11% |
Student > Bachelor | 5 | 8% |
Student > Doctoral Student | 3 | 5% |
Other | 7 | 11% |
Unknown | 13 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 12 | 19% |
Agricultural and Biological Sciences | 10 | 16% |
Medicine and Dentistry | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Nursing and Health Professions | 3 | 5% |
Other | 9 | 15% |
Unknown | 16 | 26% |