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Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage

Overview of attention for article published in Arthritis Research & Therapy, January 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#7 of 3,145)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
27 news outlets
blogs
1 blog
twitter
11 X users
wikipedia
5 Wikipedia pages
reddit
1 Redditor

Citations

dimensions_citation
281 Dimensions

Readers on

mendeley
377 Mendeley
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Title
Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4175
Pubmed ID
Authors

Carlos Sostres, Carla J Gargallo, Angel Lanas

Abstract

NSAIDs are among the most commonly used drugs worldwide and their beneficial therapeutic properties are thoroughly accepted. However, they are also associated with gastrointestinal (GI) adverse events. NSAIDs can damage the whole GI tract including a wide spectrum of lesions. About 1 to 2% of NSAID users experienced a serious GI complication during treatment. The relative risk of upper GI complications among NSAID users depends on the presence of different risk factors, including older age (>65 years), history of complicated peptic ulcer, and concomitant aspirin or anticoagulant use, in addition to the type and dose of NSAID. Some authors recently reported a decreasing trend in hospitalizations due to upper GI complications and a significant increase in those from the lower GI tract, causing the rates of these two types of GI complications to converge. NSAID-induced enteropathy has gained much attention in the last few years and an increasing number of reports have been published on this issue. Current evidence suggests that NSAIDs increase the risk of lower GI bleeding and perforation to a similar extent as that seen in the upper GI tract. Selective cyclooxygenase-2 inhibitors have the same beneficial effects as nonselective NSAIDs but with less GI toxicity in the upper GI tract and probably in the lower GI tract. Overall, mortality due to these complications has also decreased, but the in-hospital case fatality for upper and lower GI complication events has remained constant despite the new therapeutic and prevention strategies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 377 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Sudan 1 <1%
Argentina 1 <1%
Brazil 1 <1%
Unknown 373 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 74 20%
Student > Master 51 14%
Student > Doctoral Student 30 8%
Researcher 28 7%
Student > Postgraduate 28 7%
Other 70 19%
Unknown 96 25%
Readers by discipline Count As %
Medicine and Dentistry 121 32%
Pharmacology, Toxicology and Pharmaceutical Science 53 14%
Biochemistry, Genetics and Molecular Biology 23 6%
Agricultural and Biological Sciences 23 6%
Chemistry 18 5%
Other 33 9%
Unknown 106 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 238. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#150,180
of 24,584,609 outputs
Outputs from Arthritis Research & Therapy
#7
of 3,145 outputs
Outputs of similar age
#940
of 290,571 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 162 outputs
Altmetric has tracked 24,584,609 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,145 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,571 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.