Title |
Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle
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Published in |
Longevity & Healthspan, July 2013
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DOI | 10.1186/2046-2395-2-11 |
Pubmed ID | |
Authors |
James N Cobley, George K Sakellariou, Scott Murray, Sarah Waldron, Warren Gregson, Jatin G Burniston, James P Morton, Lesley A Iwanejko, Graeme L Close |
Abstract |
The aim of the present study was to determine the influence of age and habitual activity level, at rest and following a single bout of high-intensity exercise, on the levels of three proteins poly(ADP-ribose) polymerase-1 (PARP-1), cleaved-PARP-1 and poly(ADP-ribose) glycohydrolase (PARG), involved in the DNA repair and cell death responses to stress and genotoxic insults. Muscle biopsies were obtained from the vastus lateralis of young trained (22 ± 3 years, n = 6), young untrained (24 ± 4 years, n = 6), old trained (64 ± 3 years, n = 6) and old untrained (65 ± 6 years, n = 6) healthy males before, immediately after and three days following a high-intensity interval exercise bout. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 9 | 60% |
Norway | 1 | 7% |
Unknown | 5 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 47% |
Scientists | 6 | 40% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 21% |
Student > Master | 4 | 14% |
Student > Postgraduate | 3 | 10% |
Student > Bachelor | 2 | 7% |
Lecturer | 2 | 7% |
Other | 6 | 21% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 24% |
Medicine and Dentistry | 5 | 17% |
Sports and Recreations | 4 | 14% |
Agricultural and Biological Sciences | 3 | 10% |
Business, Management and Accounting | 2 | 7% |
Other | 2 | 7% |
Unknown | 6 | 21% |