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Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin

Overview of attention for article published in BMC Veterinary Research, January 2012
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Title
Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin
Published in
BMC Veterinary Research, January 2012
DOI 10.1186/1746-6148-8-245
Pubmed ID
Authors

Joline Goossens, Frank Pasmans, Elin Verbrugghe, Virginie Vandenbroucke, Siegrid De Baere, Evelyne Meyer, Freddy Haesebrouck, Patrick De Backer, Siska Croubels

Abstract

The gastrointestinal tract is the first target for the potentially harmful effects of mycotoxins after intake of mycotoxin contaminated food or feed. With deoxynivalenol (DON), T-2 toxin (T-2), fumonisin B1 (FB1) and zearalenone (ZEA) being important Fusarium toxins in the northern hemisphere, this study aimed to investigate in vitro the toxic effect of these mycotoxins on intestinal porcine epithelial cells derived from the jejunum (IPEC-J2 cells). Viability of IPEC-J2 cells as well as the proportion of apoptotic and necrotic IPEC-J2 cells was determined by flow cytometry after 72 h of exposure to the toxins. Correlatively, the integrity of the intestinal epithelial cell monolayer was studied using Transwell(®) inserts, in which the trans-epithelial electrical resistance (TEER) and passage of the antibiotics doxycycline and paromomycin were used as endpoints.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Austria 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Master 9 18%
Researcher 6 12%
Student > Bachelor 5 10%
Student > Doctoral Student 3 6%
Other 6 12%
Unknown 13 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 33%
Biochemistry, Genetics and Molecular Biology 5 10%
Veterinary Science and Veterinary Medicine 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Medicine and Dentistry 3 6%
Other 3 6%
Unknown 17 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2013.
All research outputs
#2,018,515
of 3,627,150 outputs
Outputs from BMC Veterinary Research
#308
of 609 outputs
Outputs of similar age
#47,949
of 91,850 outputs
Outputs of similar age from BMC Veterinary Research
#19
of 41 outputs
Altmetric has tracked 3,627,150 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 609 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.