Title |
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice
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Published in |
Molecular Brain, March 2013
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DOI | 10.1186/1756-6606-6-12 |
Pubmed ID | |
Authors |
Koji Ohira, Katsunori Kobayashi, Keiko Toyama, Hironori K Nakamura, Hirotaka Shoji, Keizo Takao, Rika Takeuchi, Shun Yamaguchi, Masakazu Kataoka, Shintaro Otsuka, Masami Takahashi, Tsuyoshi Miyakawa |
Abstract |
Synaptosomal-associated protein, 25 kDa (SNAP-25) regulates the exocytosis of neurotransmitters. Growing evidence suggests that SNAP-25 is involved in neuropsychiatric disorders, such as schizophrenia, attention-deficit/hyperactivity disorder, and epilepsy. Recently, increases in anxiety-related behaviors and epilepsy have been observed in SNAP-25 knock-in (KI) mice, which have a single amino acid substitution of Ala for Ser187. However, the molecular and cellular mechanisms underlying the abnormalities in this mutant remain unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
United States | 1 | 2% |
France | 1 | 2% |
Unknown | 57 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 20% |
Researcher | 9 | 15% |
Student > Bachelor | 6 | 10% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 5 | 8% |
Other | 12 | 20% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 14 | 23% |
Agricultural and Biological Sciences | 11 | 18% |
Medicine and Dentistry | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Psychology | 5 | 8% |
Other | 2 | 3% |
Unknown | 12 | 20% |