Title |
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease
|
---|---|
Published in |
Alzheimer's Research & Therapy, September 2013
|
DOI | 10.1186/alzrt204 |
Pubmed ID | |
Authors |
Andrew B Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo LaDu, Eric M Reiman, Richard J Caselli |
Abstract |
APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer's disease. Current understanding of Alzheimer's disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 55 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 35% |
Researcher | 10 | 18% |
Student > Master | 9 | 16% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 11% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 14 | 25% |
Neuroscience | 10 | 18% |
Medicine and Dentistry | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Psychology | 6 | 11% |
Other | 3 | 5% |
Unknown | 9 | 16% |