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Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease

Overview of attention for article published in Alzheimer's Research & Therapy, September 2013
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Title
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease
Published in
Alzheimer's Research & Therapy, September 2013
DOI 10.1186/alzrt204
Pubmed ID
Authors

Andrew B Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo LaDu, Eric M Reiman, Richard J Caselli

Abstract

APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer's disease. Current understanding of Alzheimer's disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 35%
Researcher 10 18%
Student > Master 9 16%
Student > Bachelor 4 7%
Student > Doctoral Student 3 5%
Other 6 11%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 25%
Neuroscience 10 18%
Medicine and Dentistry 9 16%
Biochemistry, Genetics and Molecular Biology 6 11%
Psychology 6 11%
Other 3 5%
Unknown 9 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2014.
All research outputs
#14,783,193
of 25,371,288 outputs
Outputs from Alzheimer's Research & Therapy
#1,298
of 1,464 outputs
Outputs of similar age
#109,972
of 208,959 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#11
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,959 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.