Title |
Ciliogenesis and cerebrospinal fluid flow in the developing Xenopus brain are regulated by foxj1
|
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Published in |
Cilia, September 2013
|
DOI | 10.1186/2046-2530-2-12 |
Pubmed ID | |
Authors |
Cathrin Hagenlocher, Peter Walentek, Christina Müller, Thomas Thumberger, Kerstin Feistel |
Abstract |
Circulation of cerebrospinal fluid (CSF) through the ventricular system is driven by motile cilia on ependymal cells of the brain. Disturbed ciliary motility induces the formation of hydrocephalus, a pathological accumulation of CSF resulting in ventricle dilatation and increased intracranial pressure. The mechanism by which loss of motile cilia causes hydrocephalus has not been elucidated. The aim of this study was: (1) to provide a detailed account of the development of ciliation in the brain of the African clawed frog Xenopus laevis; and (2) to analyze the relevance of ependymal cilia motility for CSF circulation and brain ventricle morphogenesis in Xenopus. |
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