Title |
Resistance of cervical adenocarcinoma cells (HeLa) to venom from the scorpion Centruroides limpidus limpidus
|
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Published in |
Journal of Venomous Animals and Toxins including Tropical Diseases, September 2013
|
DOI | 10.1186/1678-9199-19-20 |
Pubmed ID | |
Authors |
José María Eloy Contreras-Ortiz, Juan Carlos Vázquez-Chagoyán, José Simón Martínez-Castañeda, José Guillermo Estrada-Franco, José Esteban Aparicio-Burgos, Jorge Acosta-Dibarrat, Alberto Barbabosa-Pliego |
Abstract |
The venom of Centruroides limpidus limpidus (Cll) is a mixture of pharmacologically active principles. The most important of these are toxic proteins that interact both selectively and specifically with different cellular targets such as ion channels. Recently, anticancer properties of the venom from other scorpion species have been described. Studies in vitro have shown that scorpion venom induces cell death, inhibits proliferation and triggers the apoptotic pathway in different cancer cell lines. Herein, after treating human cervical adenocarcinoma (HeLa) cells with Cll crude venom, their cytotoxic activity and apoptosis induction were assessed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 25% |
Researcher | 5 | 16% |
Student > Doctoral Student | 4 | 13% |
Student > Postgraduate | 3 | 9% |
Student > Master | 3 | 9% |
Other | 5 | 16% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 22% |
Agricultural and Biological Sciences | 7 | 22% |
Medicine and Dentistry | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
Chemistry | 2 | 6% |
Other | 3 | 9% |
Unknown | 6 | 19% |