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White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation

Overview of attention for article published in Veterinary Research, January 2011
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Title
White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation
Published in
Veterinary Research, January 2011
DOI 10.1186/1297-9716-42-107
Pubmed ID
Authors

Justin J Greenlee, Jodi D Smith, Robert A Kunkle

Abstract

Interspecies transmission studies afford the opportunity to better understand the potential host range and origins of prion diseases. The purpose of this experiment was to determine susceptibility of white-tailed deer to the agent of scrapie after intracerebral inoculation and to compare clinical signs and lesions to those reported for chronic wasting disease (CWD). Deer (n = 5) were inoculated with 1 mL of a 10% (wt/vol) brain homogenate derived from a sheep clinically affected with scrapie. A non-inoculated deer was maintained as a negative control. Deer were observed daily for clinical signs of disease and euthanized and necropsied when unequivocal signs of scrapie were noted. One animal died 7 months post inoculation (pi) due to intercurrent disease. Examinations of brain tissue for the presence of the disease-associated abnormal prion protein (PrP(Sc)) by western blot (WB) and immunohistochemistry (IHC) were negative whereas IHC of lymphoid tissues was positive. Deer necropsied at 15-22 months pi were positive for scrapie by IHC and WB. Deer necropsied after 20 months pi had clinical signs of depression and progressive weight loss. Tissues with PrP(Sc) immunoreactivity included brain (at levels of cerebrum, hippocampus, colliculus, cerebellum, and brainstem), trigeminal ganglion, neurohypophysis, retina, spinal cord, and various lymphoid tissues including tonsil, retropharyngeal and mesenteric lymph nodes, Peyer's patches, and spleen. This work demonstrates for the first time that white-tailed deer are susceptible to sheep scrapie by intracerebral inoculation. To further test the susceptibility of white-tailed deer to scrapie these experiments will be repeated with a more natural route of inoculation.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 25%
Other 5 13%
Student > Master 5 13%
Student > Bachelor 4 10%
Student > Ph. D. Student 4 10%
Other 7 18%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 30%
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 5 13%
Veterinary Science and Veterinary Medicine 5 13%
Environmental Science 1 3%
Other 4 10%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2013.
All research outputs
#2,898,335
of 3,634,361 outputs
Outputs from Veterinary Research
#255
of 294 outputs
Outputs of similar age
#73,070
of 92,443 outputs
Outputs of similar age from Veterinary Research
#26
of 28 outputs
Altmetric has tracked 3,634,361 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 294 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.