Title |
T-ALL and thymocytes: a message of noncoding RNAs
|
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Published in |
Journal of Hematology & Oncology, March 2017
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DOI | 10.1186/s13045-017-0432-0 |
Pubmed ID | |
Authors |
Annelynn Wallaert, Kaat Durinck, Tom Taghon, Pieter Van Vlierberghe, Frank Speleman |
Abstract |
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Belgium | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Austria | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 23% |
Student > Master | 9 | 16% |
Researcher | 8 | 14% |
Student > Doctoral Student | 6 | 11% |
Student > Bachelor | 4 | 7% |
Other | 8 | 14% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 29 | 51% |
Medicine and Dentistry | 5 | 9% |
Agricultural and Biological Sciences | 4 | 7% |
Immunology and Microbiology | 2 | 4% |
Neuroscience | 2 | 4% |
Other | 4 | 7% |
Unknown | 11 | 19% |