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Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs

Overview of attention for article published in BMC Genomics, September 2013
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Title
Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs
Published in
BMC Genomics, September 2013
DOI 10.1186/1471-2164-14-648
Pubmed ID
Authors

Jeroen Crappé, Wim Van Criekinge, Geert Trooskens, Eisuke Hayakawa, Walter Luyten, Geert Baggerman, Gerben Menschaert

Abstract

It was long assumed that proteins are at least 100 amino acids (AAs) long. Moreover, the detection of short translation products (e.g. coded from small Open Reading Frames, sORFs) is very difficult as the short length makes it hard to distinguish true coding ORFs from ORFs occurring by chance. Nevertheless, over the past few years many such non-canonical genes (with ORFs < 100 AAs) have been discovered in different organisms like Arabidopsis thaliana, Saccharomyces cerevisiae, and Drosophila melanogaster. Thanks to advances in sequencing, bioinformatics and computing power, it is now possible to scan the genome in unprecedented scrutiny, for example in a search of this type of small ORFs.

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Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Ireland 1 <1%
Germany 1 <1%
Japan 1 <1%
Brazil 1 <1%
Unknown 154 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 36 23%
Student > Ph. D. Student 33 21%
Student > Master 26 16%
Student > Bachelor 14 9%
Student > Doctoral Student 7 4%
Other 19 12%
Unknown 25 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 59 37%
Biochemistry, Genetics and Molecular Biology 49 31%
Computer Science 5 3%
Chemistry 5 3%
Engineering 4 3%
Other 7 4%
Unknown 31 19%