Title |
Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides
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Published in |
BMC Genomics, September 2013
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DOI | 10.1186/1471-2164-14-658 |
Pubmed ID | |
Authors |
Monique Royer, Ralf Koebnik, Mélanie Marguerettaz, Valérie Barbe, Guillaume P Robin, Chrystelle Brin, Sébastien Carrere, Camila Gomez, Manuela Hügelland, Ginka H Völler, Julie Noëll, Isabelle Pieretti, Saskia Rausch, Valérie Verdier, Stéphane Poussier, Philippe Rott, Roderich D Süssmuth, Stéphane Cociancich |
Abstract |
Various bacteria can use non-ribosomal peptide synthesis (NRPS) to produce peptides or other small molecules. Conserved features within the NRPS machinery allow the type, and sometimes even the structure, of the synthesized polypeptide to be predicted. Thus, bacterial genome mining via in silico analyses of NRPS genes offers an attractive opportunity to uncover new bioactive non-ribosomally synthesized peptides. Xanthomonas is a large genus of Gram-negative bacteria that cause disease in hundreds of plant species. To date, the only known small molecule synthesized by NRPS in this genus is albicidin produced by Xanthomonas albilineans. This study aims to estimate the biosynthetic potential of Xanthomonas spp. by in silico analyses of NRPS genes with unknown function recently identified in the sequenced genomes of X. albilineans and related species of Xanthomonas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
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France | 2 | 3% |
Denmark | 1 | 1% |
India | 1 | 1% |
Unknown | 64 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 18% |
Researcher | 12 | 18% |
Student > Master | 9 | 13% |
Student > Bachelor | 6 | 9% |
Student > Postgraduate | 4 | 6% |
Other | 11 | 16% |
Unknown | 14 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 21% |
Chemistry | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Computer Science | 1 | 1% |
Other | 3 | 4% |
Unknown | 17 | 25% |