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Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegansmodel for polyglutamine disease

Overview of attention for article published in BMC Biology, September 2013
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Title
Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegansmodel for polyglutamine disease
Published in
BMC Biology, September 2013
DOI 10.1186/1741-7007-11-100
Pubmed ID
Authors

Tali Gidalevitz, Ning Wang, Tanuja Deravaj, Jasmine Alexander-Floyd, Richard I Morimoto

Abstract

Monogenic gain-of-function protein aggregation diseases, including Huntington's disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotoxic mutations is proposed to be due, at least in part, to the variability in genetic background. To address this, we examined the role of natural variation in defining the susceptibility of genetically diverse individuals to protein aggregation and toxicity, using the Caenorhabditis elegans polyglutamine model.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 2%
Belgium 1 2%
Unknown 60 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 26%
Researcher 12 19%
Student > Master 8 13%
Student > Bachelor 6 10%
Other 5 8%
Other 10 16%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 37%
Biochemistry, Genetics and Molecular Biology 22 35%
Engineering 2 3%
Chemistry 2 3%
Linguistics 1 2%
Other 6 10%
Unknown 6 10%