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X Demographics
Mendeley readers
Title |
Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegansmodel for polyglutamine disease
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Published in |
BMC Biology, September 2013
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DOI | 10.1186/1741-7007-11-100 |
Pubmed ID | |
Authors |
Tali Gidalevitz, Ning Wang, Tanuja Deravaj, Jasmine Alexander-Floyd, Richard I Morimoto |
Abstract |
Monogenic gain-of-function protein aggregation diseases, including Huntington's disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, even between individuals with similar or identical mutations. This difference in phenotypic expression of proteotoxic mutations is proposed to be due, at least in part, to the variability in genetic background. To address this, we examined the role of natural variation in defining the susceptibility of genetically diverse individuals to protein aggregation and toxicity, using the Caenorhabditis elegans polyglutamine model. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Venezuela, Bolivarian Republic of | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 60 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 26% |
Researcher | 12 | 19% |
Student > Master | 8 | 13% |
Student > Bachelor | 6 | 10% |
Other | 5 | 8% |
Other | 10 | 16% |
Unknown | 5 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 37% |
Biochemistry, Genetics and Molecular Biology | 22 | 35% |
Engineering | 2 | 3% |
Chemistry | 2 | 3% |
Linguistics | 1 | 2% |
Other | 6 | 10% |
Unknown | 6 | 10% |