Title |
Selective photoinactivation of Candida albicans in the non-vertebrate host infection model Galleria mellonella
|
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Published in |
BMC Microbiology, October 2013
|
DOI | 10.1186/1471-2180-13-217 |
Pubmed ID | |
Authors |
José Chibebe Junior, Caetano P Sabino, Xiaojiang Tan, Juliana C Junqueira, Yan Wang, Beth B Fuchs, Antonio OC Jorge, George P Tegos, Michael R Hamblin, Eleftherios Mylonakis |
Abstract |
Candida spp. are recognized as a primary agent of severe fungal infection in immunocompromised patients, and are the fourth most common cause of bloodstream infections. Our study explores treatment with photodynamic therapy (PDT) as an innovative antimicrobial technology that employs a nontoxic dye, termed a photosensitizer (PS), followed by irradiation with harmless visible light. After photoactivation, the PS produces either singlet oxygen or other reactive oxygen species (ROS) that primarily react with the pathogen cell wall, promoting permeabilization of the membrane and cell death. The emergence of antifungal-resistant Candida strains has motivated the study of antimicrobial PDT (aPDT) as an alternative treatment of these infections. We employed the invertebrate wax moth Galleria mellonella as an in vivo model to study the effects of aPDT against C. albicans infection. The effects of aPDT combined with conventional antifungal drugs were also evaluated in G. mellonella. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 1% |
Poland | 1 | 1% |
Unknown | 70 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 17% |
Student > Master | 9 | 13% |
Researcher | 7 | 10% |
Student > Doctoral Student | 7 | 10% |
Student > Bachelor | 6 | 8% |
Other | 15 | 21% |
Unknown | 16 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 26% |
Agricultural and Biological Sciences | 11 | 15% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Immunology and Microbiology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 8 | 11% |
Unknown | 17 | 24% |