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Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves

Overview of attention for article published in Veterinary Research, October 2013
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Title
Different virulence of porcine and porcine-like bovine rotavirus strains with genetically nearly identical genomes in piglets and calves
Published in
Veterinary Research, October 2013
DOI 10.1186/1297-9716-44-88
Pubmed ID
Authors

Jun-Gyu Park, Hyun-Jeong Kim, Jelle Matthijnssens, Mia Madel Alfajaro, Deok-Song Kim, Kyu-Yeol Son, Hyoung-Jun Kwon, Myra Hosmillo, Eun-Hye Ryu, Ji-Yun Kim, Rohani B Cena, Ju-Hwan Lee, Mun-Il Kang, Sang-Ik Park, Kyoung-Oh Cho

Abstract

Direct interspecies transmissions of group A rotaviruses (RVA) have been reported under natural conditions. However, the pathogenicity of RVA has never been directly compared in homologous and heterologous hosts. The bovine RVA/Cow-tc/KOR/K5/2004/G5P[7] strain, which was shown to possess a typical porcine-like genotype constellation similar to that of the G5P[7] prototype RVA/Pig-tc/USA/OSU/1977/G5P9[7] strain, was examined for its pathogenicity and compared with the porcine G5P[7] RVA/Pig-tc/KOR/K71/2006/G5P[7] strain possessing the same genotype constellation. The bovine K5 strain induced diarrhea and histopathological changes in the small intestine of piglets and calves, whereas the porcine K71 strain caused diarrhea and histopathological changes in the small intestine of piglets, but not in calves. Furthermore, the bovine K5 strain showed extra-intestinal tropisms in both piglets and calves, whereas the porcine K71 strain had extra-intestinal tropisms in piglets, but not in calves. Therefore, we performed comparative genomic analysis of the K71 and K5 RVA strains to determine whether specific mutations could be associated with these distinct clinical and pathological phenotypes. Full-length sequencing analyses for the 11 genomic segments for K71 and K5 revealed that these strains were genetically nearly identical to each other. Two nucleotide mutations were found in the 5' untranslated region (UTR) of NSP5 and the 3' UTR of NSP3, and eight amino acid mutations in VP1-VP4 and NSP2. Some of these mutations may be critical molecular determinants for RVA virulence and/or pathogenicity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 28%
Student > Master 3 12%
Professor 2 8%
Student > Bachelor 2 8%
Researcher 2 8%
Other 7 28%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 36%
Veterinary Science and Veterinary Medicine 4 16%
Biochemistry, Genetics and Molecular Biology 2 8%
Immunology and Microbiology 2 8%
Medicine and Dentistry 2 8%
Other 2 8%
Unknown 4 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2013.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from Veterinary Research
#974
of 1,337 outputs
Outputs of similar age
#158,895
of 219,840 outputs
Outputs of similar age from Veterinary Research
#22
of 26 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.