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Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

Overview of attention for article published in Journal for Immunotherapy of Cancer, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
35 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
130 Dimensions

Readers on

mendeley
274 Mendeley
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Title
Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment
Published in
Journal for Immunotherapy of Cancer, March 2017
DOI 10.1186/s40425-017-0230-9
Pubmed ID
Authors

Irene Scarfò, Marcela V. Maus

Abstract

Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches.

Twitter Demographics

The data shown below were collected from the profiles of 35 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
France 1 <1%
Norway 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 269 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 58 21%
Student > Ph. D. Student 51 19%
Student > Bachelor 29 11%
Student > Master 25 9%
Student > Doctoral Student 18 7%
Other 44 16%
Unknown 49 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 61 22%
Immunology and Microbiology 48 18%
Medicine and Dentistry 42 15%
Agricultural and Biological Sciences 30 11%
Pharmacology, Toxicology and Pharmaceutical Science 13 5%
Other 24 9%
Unknown 56 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2022.
All research outputs
#854,038
of 21,554,340 outputs
Outputs from Journal for Immunotherapy of Cancer
#186
of 2,650 outputs
Outputs of similar age
#19,616
of 284,194 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#1
of 1 outputs
Altmetric has tracked 21,554,340 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,650 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,194 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them