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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment
|
|---|---|
| Published in |
Journal for Immunotherapy of Cancer, March 2017
|
| DOI | 10.1186/s40425-017-0230-9 |
| Pubmed ID | |
| Authors |
Irene Scarfò, Marcela V. Maus |
| Abstract |
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 33% |
| France | 4 | 12% |
| Spain | 3 | 9% |
| Ireland | 1 | 3% |
| Comoros | 1 | 3% |
| Chile | 1 | 3% |
| Russia | 1 | 3% |
| Unknown | 11 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 67% |
| Scientists | 5 | 15% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
| Science communicators (journalists, bloggers, editors) | 3 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 300 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| France | 1 | <1% |
| Norway | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 295 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 59 | 20% |
| Student > Ph. D. Student | 54 | 18% |
| Student > Bachelor | 33 | 11% |
| Student > Master | 27 | 9% |
| Student > Doctoral Student | 20 | 7% |
| Other | 46 | 15% |
| Unknown | 61 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 62 | 21% |
| Immunology and Microbiology | 51 | 17% |
| Medicine and Dentistry | 44 | 15% |
| Agricultural and Biological Sciences | 30 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 5% |
| Other | 29 | 10% |
| Unknown | 70 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2022.
All research outputs
#1,162,848
of 25,734,859 outputs
Outputs from Journal for Immunotherapy of Cancer
#276
of 3,498 outputs
Outputs of similar age
#22,940
of 323,887 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#7
of 31 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,887 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.