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Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor

Overview of attention for article published in BMC Microbiology, October 2013
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1 tweeter

Citations

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63 Mendeley
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Title
Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor
Published in
BMC Microbiology, October 2013
DOI 10.1186/1471-2180-13-218
Pubmed ID
Authors

Sulochana Somasundaram, Ramaian Santhaseela Anand, Perumal Venkatesan, Chinnambedu N Paramasivan

Abstract

The resurgence of multi-drug resistant tuberculosis (MDR-TB) and HIV associated tuberculosis (TB) are of serious global concern. To contain this situation, new anti-tuberculosis drugs and reduced treatment regimens are imperative. Recently, a nitroimidazole, PA-824, has been shown to be active against both replicating and non-replicating bacteria. It is activated by the enzyme Deazaflavin-dependent nitroreductase (Ddn) present in Mycobacterium tuberculosis which catalyzes the reduction of PA-824, resulting in the release of lethal reactive nitrogen species (RNS) within the bacteria. In this context, PA-824 was analyzed for its activity against latent tuberculosis under anaerobic conditions and compared with rifampicin (RIF) and pyrazinamide (PZA). Recent mutagenesis studies have identified A76E mutation which affects the above mentioned catalysis and leads to PA-824 resistance. Hence, novel analogues which could cope up with their binding to mutant Ddn receptor were also identified through this study.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 17%
Researcher 10 16%
Student > Ph. D. Student 7 11%
Student > Postgraduate 6 10%
Student > Bachelor 6 10%
Other 16 25%
Unknown 7 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 24%
Medicine and Dentistry 14 22%
Biochemistry, Genetics and Molecular Biology 6 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Immunology and Microbiology 4 6%
Other 11 17%
Unknown 9 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2013.
All research outputs
#3,068,158
of 4,507,280 outputs
Outputs from BMC Microbiology
#610
of 906 outputs
Outputs of similar age
#67,413
of 99,656 outputs
Outputs of similar age from BMC Microbiology
#22
of 34 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 906 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.