Title |
H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
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Published in |
Veterinary Research, October 2013
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DOI | 10.1186/1297-9716-44-92 |
Pubmed ID | |
Authors |
Young Myong Kang, Heui Man Kim, Keun Bon Ku, Eun Hye Park, Jung Yum, Sang Heui Seo |
Abstract |
Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 25% |
Other | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Researcher | 2 | 10% |
Professor | 2 | 10% |
Other | 3 | 15% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 5 | 25% |
Medicine and Dentistry | 3 | 15% |
Immunology and Microbiology | 3 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Unspecified | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 25% |