Title |
Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma
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Published in |
BMC Molecular and Cell Biology, September 2013
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DOI | 10.1186/1471-2121-14-44 |
Pubmed ID | |
Authors |
Yue Cheng, Arthur Kwok Leung Cheung, Josephine Mun Yee Ko, Yee Peng Phoon, Pui Man Chiu, Paulisally Hau Yi Lo, Marian L Waterman, Maria Li Lung |
Abstract |
A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks. There are ongoing debates as to whether and how the Wnt/β-catenin signaling is involved in the control of pluripotency gene networks. Additionally, whether physiological β-catenin signaling generates stem-like cells through interactions with other pathways is as yet unclear. The nasopharyngeal carcinoma HONE1 cells have low expression of β-catenin and wild-type expression of p53, which provided a possibility to study regulatory mechanism of stemness networks induced by physiological levels of Wnt signaling in these cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Hong Kong | 1 | 2% |
United States | 1 | 2% |
Portugal | 1 | 2% |
Unknown | 51 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 30% |
Student > Master | 8 | 15% |
Researcher | 6 | 11% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 3 | 6% |
Other | 9 | 17% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 24% |
Agricultural and Biological Sciences | 13 | 24% |
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Chemical Engineering | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 6 | 11% |
Unknown | 9 | 17% |