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Impaired liver regeneration is associated with reduced cyclin B1 in natural killer T cell-deficient mice

Overview of attention for article published in BMC Gastroenterology, March 2017
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Title
Impaired liver regeneration is associated with reduced cyclin B1 in natural killer T cell-deficient mice
Published in
BMC Gastroenterology, March 2017
DOI 10.1186/s12876-017-0600-2
Pubmed ID
Authors

Ami Ben Ya’acov, Hadar Meir, Lydia Zolotaryova, Yaron Ilan, Eyal Shteyer

Abstract

It has been shown that the proportion of natural killer T cells is markedly elevated during liver regeneration and their activation under different conditions can modulate this process. As natural killer T cells and liver injury are central in liver regeneration, elucidating their role is important. The aim of the current study is to explore the role of natural killer T cells in impaired liver regeneration. Concanvalin A was injected 4 days before partial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-treated mice. Ki-67 and proliferating cell nuclear antigen were used to measure hepatocytes proliferation. Expression of hepatic cyclin B1 and proliferating cell nuclear antigen were evaluated by Western Blot and liver injury was assessed by ALT and histology. Natural killer T cells- deficient or mice injected with anti CD1d antibodies exhibited reduced liver regeneration. These mice were considerably resistant to ConA-induced liver injury. In the absence of NKT cells hepatic proliferating cell nuclear antigen and cyclin B1 decreased in mice injected with Concanvalin A before partial hepatectomy. This was accompanied with reduced serum interleukin-6 levels. Natural killer T cells play an important role in liver regeneration, which is associated with cyclin B1 and interleukin-6.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 22%
Professor 1 11%
Student > Ph. D. Student 1 11%
Researcher 1 11%
Student > Postgraduate 1 11%
Other 0 0%
Unknown 3 33%
Readers by discipline Count As %
Immunology and Microbiology 3 33%
Medicine and Dentistry 2 22%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Unknown 3 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2017.
All research outputs
#8,010,575
of 9,240,924 outputs
Outputs from BMC Gastroenterology
#602
of 719 outputs
Outputs of similar age
#219,217
of 260,025 outputs
Outputs of similar age from BMC Gastroenterology
#6
of 8 outputs
Altmetric has tracked 9,240,924 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 719 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.