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Title |
Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity
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Published in |
Critical Care, October 2013
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DOI | 10.1186/cc13049 |
Pubmed ID | |
Abstract |
Sepsis is characterized by systemic immune activation and neutrophil-mediated endothelial barrier integrity compromise, contributing to end-organ dysfunction. Studies evaluating endothelial barrier dysfunction induced by neutrophils from septic patients are lacking, despite its clinical significance. We hypothesized that septic neutrophils would cause characteristic patterns of endothelial barrier dysfunction, distinct from experimental stimulation of normal neutrophils, and that treatment with the immunomodulatory drug β-glucan would attenuate this effect. |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 1% |
Italy | 1 | 1% |
Australia | 1 | 1% |
Brazil | 1 | 1% |
Belgium | 1 | 1% |
Romania | 1 | 1% |
United States | 1 | 1% |
Unknown | 77 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 17% |
Researcher | 13 | 15% |
Other | 11 | 13% |
Student > Bachelor | 9 | 11% |
Student > Master | 8 | 10% |
Other | 18 | 21% |
Unknown | 11 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 31% |
Agricultural and Biological Sciences | 16 | 19% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Immunology and Microbiology | 7 | 8% |
Nursing and Health Professions | 3 | 4% |
Other | 8 | 10% |
Unknown | 17 | 20% |