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Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity

Overview of attention for article published in Critical Care, October 2013
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Title
Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity
Published in
Critical Care, October 2013
DOI 10.1186/cc13049
Pubmed ID
Abstract

Sepsis is characterized by systemic immune activation and neutrophil-mediated endothelial barrier integrity compromise, contributing to end-organ dysfunction. Studies evaluating endothelial barrier dysfunction induced by neutrophils from septic patients are lacking, despite its clinical significance. We hypothesized that septic neutrophils would cause characteristic patterns of endothelial barrier dysfunction, distinct from experimental stimulation of normal neutrophils, and that treatment with the immunomodulatory drug β-glucan would attenuate this effect.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Italy 1 1%
Australia 1 1%
Brazil 1 1%
Belgium 1 1%
Romania 1 1%
United States 1 1%
Unknown 70 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Researcher 13 17%
Other 11 14%
Student > Bachelor 9 12%
Student > Master 8 10%
Other 15 19%
Unknown 8 10%
Readers by discipline Count As %
Medicine and Dentistry 26 34%
Agricultural and Biological Sciences 14 18%
Biochemistry, Genetics and Molecular Biology 7 9%
Immunology and Microbiology 7 9%
Nursing and Health Professions 2 3%
Other 7 9%
Unknown 14 18%