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Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity

Overview of attention for article published in Critical Care, October 2013
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Mentioned by

patent
2 patents

Citations

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76 Dimensions

Readers on

mendeley
86 Mendeley
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Title
Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity
Published in
Critical Care, October 2013
DOI 10.1186/cc13049
Pubmed ID
Authors

Elizabeth D Fox, Daithi S Heffernan, William G Cioffi, Jonathan S Reichner

Abstract

Sepsis is characterized by systemic immune activation and neutrophil-mediated endothelial barrier integrity compromise, contributing to end-organ dysfunction. Studies evaluating endothelial barrier dysfunction induced by neutrophils from septic patients are lacking, despite its clinical significance. We hypothesized that septic neutrophils would cause characteristic patterns of endothelial barrier dysfunction, distinct from experimental stimulation of normal neutrophils, and that treatment with the immunomodulatory drug β-glucan would attenuate this effect.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Italy 1 1%
Australia 1 1%
Brazil 1 1%
Belgium 1 1%
Romania 1 1%
United States 1 1%
Unknown 79 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 19%
Researcher 13 15%
Other 11 13%
Student > Bachelor 9 10%
Student > Master 8 9%
Other 17 20%
Unknown 12 14%
Readers by discipline Count As %
Medicine and Dentistry 26 30%
Agricultural and Biological Sciences 15 17%
Biochemistry, Genetics and Molecular Biology 9 10%
Immunology and Microbiology 7 8%
Nursing and Health Professions 3 3%
Other 8 9%
Unknown 18 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2023.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Critical Care
#4,397
of 6,554 outputs
Outputs of similar age
#75,767
of 222,254 outputs
Outputs of similar age from Critical Care
#52
of 107 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,254 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.