Title |
Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease
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Published in |
Journal of Translational Medicine, October 2013
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DOI | 10.1186/1479-5876-11-255 |
Pubmed ID | |
Authors |
Lee Campbell, Ghaith Al-Jayyoussi, Robert Gutteridge, Nigel Gumbleton, Rosie Griffiths, Simon Gumbleton, Mathew W Smith, David FR Griffiths, Mark Gumbleton |
Abstract |
Up to 40% of patients initially diagnosed with clinically-confined renal cell carcinoma (RCC) and who undergo curative surgery will nevertheless relapse with metastatic disease (mRCC) associated with poor long term survival. The discovery of novel prognostic/predictive biomarkers and drug targets is needed and in this context the aim of the current study was to investigate a putative caveolin-1/ERK signalling axis in clinically confined RCC, and to examine in a panel of RCC cell lines the effects of caveolin-1 (Cav-1) on pathological processes (invasion and growth) and select signalling pathways. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 21% |
Student > Ph. D. Student | 5 | 18% |
Student > Bachelor | 4 | 14% |
Professor | 2 | 7% |
Student > Doctoral Student | 1 | 4% |
Other | 5 | 18% |
Unknown | 5 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 36% |
Medicine and Dentistry | 5 | 18% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Psychology | 3 | 11% |
Nursing and Health Professions | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 18% |