Title |
Acrolein exposure suppresses antigen-induced pulmonary inflammation
|
---|---|
Published in |
Respiratory Research, October 2013
|
DOI | 10.1186/1465-9921-14-107 |
Pubmed ID | |
Authors |
Page C Spiess, David Kasahara, Aida Habibovic, Milena Hristova, Matthew J Randall, Matthew E Poynter, Albert van der Vliet |
Abstract |
Adverse health effects of tobacco smoke arise partly from its influence on innate and adaptive immune responses, leading to impaired innate immunity and host defense. The impact of smoking on allergic asthma remains unclear, with various reports demonstrating that cigarette smoke enhances asthma development but can also suppress allergic airway inflammation. Based on our previous findings that immunosuppressive effects of smoking may be largely attributed to one of its main reactive electrophiles, acrolein, we explored the impact of acrolein exposure in a mouse model of ovalbumin (OVA)-induced allergic asthma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 50 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 29% |
Student > Ph. D. Student | 9 | 18% |
Student > Master | 5 | 10% |
Student > Bachelor | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 7 | 14% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 22% |
Agricultural and Biological Sciences | 11 | 22% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Nursing and Health Professions | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 6 | 12% |
Unknown | 14 | 27% |