Title |
Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters
|
---|---|
Published in |
BMC Microbiology, May 2013
|
DOI | 10.1186/1471-2180-13-98 |
Pubmed ID | |
Authors |
Wei Hao Zheng, Åke Västermark, Maksim A Shlykov, Vamsee Reddy, Eric I Sun, Milton H Saier |
Abstract |
The ATP-Binding Cassette (ABC) functional superfamily includes integral transmembrane exporters that have evolved three times independently, forming three families termed ABC1, ABC2 and ABC3, upon which monophyletic ATPases have been superimposed for energy-coupling purposes [e.g., J Membr Biol 231(1):1-10, 2009]. The goal of the work reported in this communication was to understand how the integral membrane constituents of ABC uptake transporters with different numbers of predicted or established transmembrane segments (TMSs) evolved. In a few cases, high resolution 3-dimensional structures were available, and in these cases, their structures plus primary sequence analyses allowed us to predict evolutionary pathways of origin. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Sweden | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 24% |
Student > Master | 10 | 18% |
Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 8 | 15% |
Student > Doctoral Student | 3 | 5% |
Other | 5 | 9% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 36% |
Agricultural and Biological Sciences | 20 | 36% |
Chemistry | 3 | 5% |
Psychology | 1 | 2% |
Environmental Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 8 | 15% |