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Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

Overview of attention for article published in Lipids in Health and Disease, March 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

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5 tweeters
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1 video uploader

Citations

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45 Dimensions

Readers on

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103 Mendeley
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Title
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Published in
Lipids in Health and Disease, March 2017
DOI 10.1186/s12944-017-0461-2
Pubmed ID
Authors

Tingting Shang, Liang Liu, Jia Zhou, Mingzhen Zhang, Qinling Hu, Min Fang, Yongning Wu, Ping Yao, Zhiyong Gong

Abstract

A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. However, the pathogenesis of hepatic lipid accumulation is not completely understood. Therefore, the present study explored the effects of dietary supplementation of various ratios of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on a high-fat diet-induced lipid metabolism disorder and the concurrent liver damage. Using high-fat diet-fed C57BL/6 J mice as the animal model, diets of various ratios of DHA/EPA (2:1, 1:1, and 1:2) with an n-6/n-3 ratio of 4:1 were prepared using fish and algae oils enriched in DHA and/or EPA and sunflower seed oils to a small extent instead of the high-fat diet. Significantly decreased hepatic lipid deposition, body weight, serum lipid profile, inflammatory reactions, lipid peroxidation, and expression of adipogenesis-related proteins and inflammatory factors were observed for mice that were on a diet supplemented with DHA/EPA compared to those in the high-fat control group. The DHA/EPA 1:2 group showed lower serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol levels, lower SREBP-1C, FAS, and ACC-1 relative mRNA expression, and higher Fra1 mRNA expression, with higher relative mRNA expression of enzymes such as AMPK, PPARα, and HSL observed in the DHA/EPA 1:1 group. Lower liver TC and TG levels and higher superoxide dismutase levels were found in the DHA/EPA 2:1 group. Nonetheless, no other notable effects were observed on the biomarkers mentioned above in the groups treated with DHA/EPA compared with the DHA group. The results showed that supplementation with a lower DHA/EPA ratio seems to be more effective at alleviating high-fat diet-induced liver damage in mice, and a DHA/EPA ratio of 1:2 mitigated inflammatory risk factors. These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 103 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 18%
Student > Ph. D. Student 17 17%
Student > Master 13 13%
Student > Doctoral Student 11 11%
Student > Bachelor 11 11%
Other 16 16%
Unknown 16 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 22%
Medicine and Dentistry 13 13%
Nursing and Health Professions 9 9%
Agricultural and Biological Sciences 8 8%
Chemistry 5 5%
Other 16 16%
Unknown 29 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2021.
All research outputs
#6,459,299
of 20,111,379 outputs
Outputs from Lipids in Health and Disease
#413
of 1,332 outputs
Outputs of similar age
#106,395
of 280,506 outputs
Outputs of similar age from Lipids in Health and Disease
#1
of 1 outputs
Altmetric has tracked 20,111,379 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,332 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,506 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them