Title |
Polydatin, a natural precursor of resveratrol, induces cell cycle arrest and differentiation of human colorectal Caco-2 cell
|
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Published in |
Journal of Translational Medicine, October 2013
|
DOI | 10.1186/1479-5876-11-264 |
Pubmed ID | |
Authors |
Salvatore De Maria, Ilaria Scognamiglio, Angela Lombardi, Nicola Amodio, Michele Caraglia, Maria Cartenì, Gianpietro Ravagnan, Paola Stiuso |
Abstract |
Human colon adenocarcinoma cells are resistant to chemotherapeutic agents, such as anthracyclines, that induce death by increasing the reactive oxygen species. A number of studies have been focused on chemo-preventive use of resveratrol as antioxidant against cardiovascular diseases, aging and cancer. While resveratrol cytotoxic action was due to its pro-oxidant properties. In this study, we investigate whether the Resveratrol (trans-3,5,49-trihydroxystilbene) and its natural precursor Polydatin (resveratrol-3-O-b-mono-D-glucoside, the glycoside form of resveratrol) combination, might have a cooperative antitumor effect on either growing or differentiated human adenocarcinoma colon cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 33% |
Portugal | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Kenya | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 14% |
Student > Ph. D. Student | 8 | 14% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Other | 4 | 7% |
Other | 9 | 16% |
Unknown | 17 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Medicine and Dentistry | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Chemistry | 2 | 4% |
Other | 8 | 14% |
Unknown | 19 | 33% |