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Transcriptional regulation and its misregulation in Alzheimer’s disease

Overview of attention for article published in Molecular Brain, October 2013
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  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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3 X users

Citations

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53 Dimensions

Readers on

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104 Mendeley
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Title
Transcriptional regulation and its misregulation in Alzheimer’s disease
Published in
Molecular Brain, October 2013
DOI 10.1186/1756-6606-6-44
Pubmed ID
Authors

Xiao-Fen Chen, Yun-wu Zhang, Huaxi Xu, Guojun Bu

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition. Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression. In recent years, important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes. In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Unknown 103 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 24%
Student > Bachelor 24 23%
Researcher 15 14%
Student > Master 9 9%
Student > Doctoral Student 5 5%
Other 10 10%
Unknown 16 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 31%
Agricultural and Biological Sciences 23 22%
Neuroscience 9 9%
Medicine and Dentistry 5 5%
Psychology 3 3%
Other 11 11%
Unknown 21 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2013.
All research outputs
#16,045,990
of 25,371,288 outputs
Outputs from Molecular Brain
#598
of 1,198 outputs
Outputs of similar age
#128,883
of 224,352 outputs
Outputs of similar age from Molecular Brain
#4
of 13 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,352 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.