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Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice

Overview of attention for article published in Journal of Neuroinflammation, February 2011
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Title
Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
Published in
Journal of Neuroinflammation, February 2011
DOI 10.1186/1742-2094-8-12
Pubmed ID
Authors

Sook-Eun Park, Robert Dantzer, Keith W Kelley, Robert H McCusker

Abstract

Exogenous administration of insulin-like growth factor (IGF)-I has anti-depressant properties in rodent models of depression. However, nothing is known about the anti-depressant properties of IGF-I during inflammation, nor have mechanisms by which IGF-I alters behavior following activation of the innate immune system been clarified. We hypothesized that central IGF-I would diminish depressive-like behavior on a background of an inflammatory response and that it would do so by inducing expression of the brain-derived neurotrophic factor (BDNF) while decreasing pro-inflammatory cytokine expression in the brain. IGF-I (1,000 ng) was administered intracerebroventricularly (i.c.v.) to CD-1 mice. Mice were subsequently given lipopolysaccharide i.c.v. (LPS, 10 ng). Sickness and depressive-like behaviors were assessed followed by analysis of brain steady state mRNA expression. Central LPS elicited typical transient signs of sickness of mice, including body weight loss, reduced feed intake and decreased social exploration toward a novel juvenile. Similarly, LPS increased time of immobility in the tail suspension test (TST). Pretreatment with IGF-I or antidepressants significantly decreased duration of immobility in the TST in both the absence and presence of LPS. To elucidate the mechanisms underlying the anti-depressant action of IGF-I, we quantified steady-state mRNA expression of inflammatory mediators in whole brain using real-time RT-PCR. LPS increased, whereas IGF-I decreased, expression of inflammatory markers interleukin-1ß (IL-1ß), tumor necrosis factor-(TNF)α, inducible nitric oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP). Moreover, IGF-I increased expression of BDNF. These results indicate that IGF-I down regulates glial activation and induces expression of an endogenous growth factor that shares anti-depressant activity. These actions of IGF-I parallel its ability to diminish depressive-like behavior.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
United States 5 4%
Chile 1 <1%
Russia 1 <1%
Italy 1 <1%
Croatia 1 <1%
Poland 1 <1%
Unknown 130 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 25 18%
Student > Ph. D. Student 24 17%
Researcher 17 12%
Student > Doctoral Student 13 9%
Student > Bachelor 13 9%
Other 25 18%
Unknown 23 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 21%
Neuroscience 28 20%
Medicine and Dentistry 17 12%
Psychology 13 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Other 14 10%
Unknown 31 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Journal of Neuroinflammation
#2,056
of 2,614 outputs
Outputs of similar age
#162,642
of 183,582 outputs
Outputs of similar age from Journal of Neuroinflammation
#32
of 32 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,614 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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