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A randomized trial to compare exercise treatment methods for patients after total knee replacement: protocol paper

Overview of attention for article published in BMC Musculoskeletal Disorders, October 2015
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Title
A randomized trial to compare exercise treatment methods for patients after total knee replacement: protocol paper
Published in
BMC Musculoskeletal Disorders, October 2015
DOI 10.1186/s12891-015-0761-5
Pubmed ID
Authors

Sara R. Piva, Charity G. Moore, Michael Schneider, Alexandra B. Gil, Gustavo J. Almeida, James J. Irrgang

Abstract

Although the outcome of total knee replacement (TKR) is favorable, surgery alone fails to resolve the functional limitations and physical inactivity that existed prior to surgery. Exercise is likely the only intervention capable of improving these persistent limitations, but exercises have to be performed with intensity sufficient to promote significant changes, at levels that cannot be tolerated until later stages post TKR. The current evidence is limited regarding the effectiveness of exercise at a later stage post TKR. To that end, this study aims to compare the outcomes of physical function and physical activity between 3 treatment groups: clinic-based individual outpatient rehabilitative exercise during 12 weeks, community-based group exercise classes during 12 weeks, and usual medical care (wait-listed control group). The secondary aim is to identify baseline predictors of functional recovery for the exercise groups. This protocol paper describes a comparative effectiveness study, designed as a 3-group single-blind randomized clinical trial. Two hundred and forty older adults who underwent TKR at least 2 months prior will be randomized into one of the three treatment approaches. Data will be collected at baseline, 3 months, and 6 months. The wait-listed control group will be randomized to one of the 2 exercise groups after 6 months of study participation, and will complete a 9-month follow-up. Primary outcome is physical function measured by the Western Ontario and McMaster Universities Osteoarthritis Index Physical Function Subscale (WOMAC-PF). Physical function is also measured by performance-based tests. Secondary outcomes include performance-based tests and physical activity assessed by a patient-reported survey and accelerometry-based physical activity monitors. Exploratory outcomes include adherence, co-interventions, attrition, and adverse events including number of falls. Linear mixed models will be fitted to compare the changes in outcome across groups. Logistic regression will identify patient characteristics that predict functional recovery in the exercise groups. Instrumental variable methods will be used to estimate the efficacy of the interventions in the presence of non-compliance. Results will inform recommendations on exercise programs to improve physical function and activity for patients at the later stage post TKR and help tailor interventions according with patients' characteristics. ClinicalTrials.gov Identifier NCT02237911 .

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 18%
Researcher 8 9%
Student > Ph. D. Student 8 9%
Student > Bachelor 8 9%
Professor 4 5%
Other 16 19%
Unknown 26 31%
Readers by discipline Count As %
Medicine and Dentistry 16 19%
Nursing and Health Professions 13 15%
Sports and Recreations 6 7%
Biochemistry, Genetics and Molecular Biology 3 4%
Unspecified 3 4%
Other 13 15%
Unknown 31 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2019.
All research outputs
#15,452,475
of 22,962,258 outputs
Outputs from BMC Musculoskeletal Disorders
#2,483
of 4,085 outputs
Outputs of similar age
#164,708
of 280,451 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#53
of 79 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,085 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,451 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.