Title |
Emerging concepts in liquid biopsies
|
---|---|
Published in |
BMC Medicine, April 2017
|
DOI | 10.1186/s12916-017-0840-6 |
Pubmed ID | |
Authors |
Samantha Perakis, Michael R. Speicher |
Abstract |
Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tumor cells, circulating tumor DNA, and tumor-derived exosomes, often referred to as "liquid biopsies", may enable tumor genome characterization by minimally invasive means. Indeed, multiple studies have described how molecular information about parent tumors can be extracted from these components. Here, we briefly summarize current technologies and then elaborate on emerging novel concepts that may further propel the field. We address normal and detectable mutation levels in the context of our current knowledge regarding the gradual accumulation of mutations during aging and in light of technological limitations. Finally, we discuss whether liquid biopsies are ready to be used in routine clinical practice. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 10% |
Sweden | 1 | 10% |
United Kingdom | 1 | 10% |
Unknown | 7 | 70% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 80% |
Scientists | 1 | 10% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | <1% |
United States | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 384 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 66 | 17% |
Researcher | 64 | 17% |
Student > Master | 47 | 12% |
Student > Bachelor | 34 | 9% |
Other | 29 | 7% |
Other | 50 | 13% |
Unknown | 97 | 25% |
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Medicine and Dentistry | 62 | 16% |
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Engineering | 16 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 3% |
Other | 37 | 10% |
Unknown | 118 | 30% |