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Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

Overview of attention for article published in Systematic Reviews, April 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

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4 tweeters

Citations

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12 Dimensions

Readers on

mendeley
154 Mendeley
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Title
Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
Published in
Systematic Reviews, April 2017
DOI 10.1186/s13643-017-0466-y
Pubmed ID
Authors

Catalá-López, Ferrán, Hutton, Brian, Driver, Jane A., Page, Matthew J., Ridao, Manuel, Valderas, José M., Alonso-Arroyo, Adolfo, Forés-Martos, Jaume, Martínez, Salvador, Gènova-Maleras, Ricard, Macías-Saint-Gerons, Diego, Crespo-Facorro, Benedicto, Vieta, Eduard, Valencia, Alfonso, Tabarés-Seisdedos, Rafael, Ferrán Catalá-López, Brian Hutton, Jane A. Driver, Matthew J. Page, Manuel Ridao, José M. Valderas, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Salvador Martínez, Ricard Gènova-Maleras, Diego Macías-Saint-Gerons, Benedicto Crespo-Facorro, Eduard Vieta, Alfonso Valencia, Rafael Tabarés-Seisdedos

Abstract

The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer. We will perform an umbrella review of systematic reviews and conduct updated meta-analyses of observational studies (cohort and case-control) investigating the association between central nervous system disorders and the risk of developing or dying from any cancer or specific types of cancer. Searches involving PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science will be used to identify systematic reviews and meta-analyses of observational studies. In addition, online databases will be checked for observational studies published outside the time frames of previous reviews. Eligible central nervous system disorders will be Alzheimer's disease, anorexia nervosa, amyotrophic lateral sclerosis, autism spectrum disorders, bipolar disorder, depression, Down's syndrome, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's disease and schizophrenia. The primary outcomes will be cancer incidence and cancer mortality in association with a central nervous system disorder. Secondary outcome measures will be site-specific cancer incidence and mortality, respectively. Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles. Data will be abstracted, and study quality/risk of bias will be appraised by two reviewers independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects meta-analyses of primary observational studies will be conducted where appropriate. Parameters for exploring statistical heterogeneity are pre-specified. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. Our study will establish the extent of the epidemiological evidence underlying the associations between central nervous system disorders and cancer and will provide a rigorous and updated synthesis of a range of important site-specific cancer outcomes. PROSPERO CRD42016052762.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 154 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 17%
Student > Ph. D. Student 22 14%
Researcher 21 14%
Student > Bachelor 14 9%
Student > Doctoral Student 12 8%
Other 27 18%
Unknown 32 21%
Readers by discipline Count As %
Medicine and Dentistry 32 21%
Psychology 24 16%
Nursing and Health Professions 15 10%
Biochemistry, Genetics and Molecular Biology 10 6%
Neuroscience 7 5%
Other 24 16%
Unknown 42 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2017.
All research outputs
#6,084,297
of 11,317,953 outputs
Outputs from Systematic Reviews
#544
of 827 outputs
Outputs of similar age
#113,060
of 265,144 outputs
Outputs of similar age from Systematic Reviews
#29
of 36 outputs
Altmetric has tracked 11,317,953 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 827 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,144 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.