Title |
Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders
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Published in |
Molecular Brain, April 2017
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DOI | 10.1186/s13041-017-0290-2 |
Pubmed ID | |
Authors |
Jackie J. Liu, Kevin P. Grace, Richard L. Horner, Miguel A. Cortez, Yiwen Shao, Zhengping Jia |
Abstract |
Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitation/inhibition may contribute to various aspects of ASD, including sleep impairments. Following the identification of Nlgn3(R451C) mutation in patients with ASD, its effects on synaptic transmission and social behaviours have been examined extensively in the mouse model. However, the contributory role of this mutation to sleep impairments in ASD remains unknown. In this study, we showed that Nlgn3(R451C) knock-in mice, an established genetic model for ASD, exhibited normal duration and distribution of sleep/wake states but significantly altered electroencephalography (EEG) power spectral profiles for wake and sleep. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 15% |
Unspecified | 6 | 12% |
Student > Bachelor | 6 | 12% |
Researcher | 5 | 10% |
Student > Postgraduate | 5 | 10% |
Other | 9 | 17% |
Unknown | 13 | 25% |
Readers by discipline | Count | As % |
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Neuroscience | 9 | 17% |
Medicine and Dentistry | 7 | 13% |
Psychology | 6 | 12% |
Unspecified | 5 | 10% |
Agricultural and Biological Sciences | 4 | 8% |
Other | 7 | 13% |
Unknown | 14 | 27% |