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Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication

Overview of attention for article published in Retrovirology, October 2013
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1 X user

Citations

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31 Mendeley
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Title
Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication
Published in
Retrovirology, October 2013
DOI 10.1186/1742-4690-10-120
Pubmed ID
Authors

Leia K Miller, Yoshifumi Kobayashi, Chiann-Chyi Chen, Timothy A Russnak, Yacov Ron, Joseph P Dougherty

Abstract

Existing highly active antiretroviral therapy (HAART) effectively controls viral replication in human immunodeficiency virus type 1 (HIV-1) infected individuals but cannot completely eradicate the infection, at least in part due to the persistence of latently infected cells. One strategy that is being actively pursued to eliminate the latent aspect of HIV-1 infection involves therapies combining latency antagonists with HAART. However, discordant pharmacokinetics between these types of drugs can potentially create sites of active viral replication within certain tissues that might be impervious to HAART.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 26%
Researcher 5 16%
Student > Master 5 16%
Student > Bachelor 3 10%
Professor 3 10%
Other 3 10%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 26%
Biochemistry, Genetics and Molecular Biology 6 19%
Medicine and Dentistry 5 16%
Immunology and Microbiology 3 10%
Neuroscience 2 6%
Other 3 10%
Unknown 4 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Retrovirology
#955
of 1,104 outputs
Outputs of similar age
#157,881
of 211,997 outputs
Outputs of similar age from Retrovirology
#40
of 50 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,104 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,997 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.