Title |
Molecular targets of natural health products in arthritis
|
---|---|
Published in |
Arthritis Research & Therapy, February 2011
|
DOI | 10.1186/ar3222 |
Pubmed ID | |
Authors |
Sarah Khalifé, Muhammad Zafarullah |
Abstract |
Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue of Arthritis Research and Therapy, Haqqi and colleagues characterized IL-1-activated mitogen-activated protein kinase kinase 3 (MKK3) and p38-mitogen-activated protein kinase (MAPK) isoforms in human OA chondrocytes. The cartilageprotective mechanisms of pomegranate extract involve diminishing MKK3-activated p38α, JNK, NF-κB and Runx2 pathways, which regulate inflammatory proteins and cartilage-destroying proteases. Epigallocatechin- 3-gallate, resveratrol, curcumin and other NHP active ingredients suppress multiple inflammatory and catabolic molecular mediators of arthritis. Non-toxicity, reduced severity and incidence of arthritis in animal models warrant testing NHP active ingredients for preventing human OA and RA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
India | 1 | 2% |
United States | 1 | 2% |
Canada | 1 | 2% |
Unknown | 46 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 14% |
Student > Master | 6 | 12% |
Professor | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Other | 4 | 8% |
Other | 9 | 18% |
Unknown | 15 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 20% |
Agricultural and Biological Sciences | 10 | 20% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 5 | 10% |
Unknown | 18 | 36% |