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Molecular targets of natural health products in arthritis

Overview of attention for article published in Arthritis Research & Therapy, February 2011
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Citations

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Title
Molecular targets of natural health products in arthritis
Published in
Arthritis Research & Therapy, February 2011
DOI 10.1186/ar3222
Pubmed ID
Authors

Sarah Khalifé, Muhammad Zafarullah

Abstract

Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue of Arthritis Research and Therapy, Haqqi and colleagues characterized IL-1-activated mitogen-activated protein kinase kinase 3 (MKK3) and p38-mitogen-activated protein kinase (MAPK) isoforms in human OA chondrocytes. The cartilageprotective mechanisms of pomegranate extract involve diminishing MKK3-activated p38α, JNK, NF-κB and Runx2 pathways, which regulate inflammatory proteins and cartilage-destroying proteases. Epigallocatechin- 3-gallate, resveratrol, curcumin and other NHP active ingredients suppress multiple inflammatory and catabolic molecular mediators of arthritis. Non-toxicity, reduced severity and incidence of arthritis in animal models warrant testing NHP active ingredients for preventing human OA and RA.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
India 1 2%
United States 1 2%
Canada 1 2%
Unknown 46 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 14%
Student > Master 6 12%
Professor 5 10%
Student > Doctoral Student 4 8%
Other 4 8%
Other 9 18%
Unknown 15 30%
Readers by discipline Count As %
Medicine and Dentistry 10 20%
Agricultural and Biological Sciences 10 20%
Biochemistry, Genetics and Molecular Biology 3 6%
Nursing and Health Professions 2 4%
Immunology and Microbiology 2 4%
Other 5 10%
Unknown 18 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2015.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#2,907
of 3,381 outputs
Outputs of similar age
#173,158
of 193,347 outputs
Outputs of similar age from Arthritis Research & Therapy
#36
of 40 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.