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Mendeley readers
Attention Score in Context
| Title |
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer’s disease
|
|---|---|
| Published in |
Alzheimer's Research & Therapy, March 2017
|
| DOI | 10.1186/s13195-017-0249-7 |
| Pubmed ID | |
| Authors |
Frances C. Quevenco, Maria G. Preti, Jiri M. G. van Bergen, Jun Hua, Michael Wyss, Xu Li, Simon J. Schreiner, Stefanie C. Steininger, Rafael Meyer, Irene B. Meier, Adam M. Brickman, Sandra E. Leh, Anton F. Gietl, Alfred Buck, Roger M. Nitsch, Klaas P. Pruessmann, Peter C. M. van Zijl, Christoph Hock, Dimitri Van De Ville, Paul G. Unschuld |
| Abstract |
The incidence of Alzheimer's disease (AD) strongly relates to advanced age and progressive deposition of cerebral amyloid-beta (Aβ), hyperphosphorylated tau, and iron. The purpose of this study was to investigate the relationship between cerebral dynamic functional connectivity and variability of long-term cognitive performance in healthy, elderly subjects, allowing for local pathology and genetic risk. Thirty seven participants (mean (SD) age 74 (6.0) years, Mini-Mental State Examination 29.0 (1.2)) were dichotomized based on repeated neuropsychological test performance within 2 years. Cerebral Aβ was measured by (11)C Pittsburgh Compound-B positron emission tomography, and iron by quantitative susceptibility mapping magnetic resonance imaging (MRI) at an ultra-high field strength of 7 Tesla (7T). Dynamic functional connectivity patterns were investigated by resting-state functional MRI at 7T and tested for interactive effects with genetic AD risk (apolipoprotein E (ApoE)-ε4 carrier status). A relationship between low episodic memory and a lower expression of anterior-posterior connectivity was seen (F(9,27) = 3.23, p < 0.008), moderated by ApoE-ε4 (F(9,27) = 2.22, p < 0.005). Inherent node-strength was related to local iron (F(5,30) = 13.2; p < 0.022). Our data indicate that altered dynamic anterior-posterior brain connectivity is a characteristic of low memory performance in the subclinical range and genetic risk for AD in the elderly. As the observed altered brain network properties are associated with increased local iron, our findings may reflect secondary neuronal changes due to pathologic processes including oxidative stress. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 18% |
| Student > Ph. D. Student | 14 | 14% |
| Student > Bachelor | 10 | 10% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 7 | 7% |
| Other | 14 | 14% |
| Unknown | 29 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 17 | 17% |
| Neuroscience | 17 | 17% |
| Medicine and Dentistry | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Sports and Recreations | 3 | 3% |
| Other | 15 | 15% |
| Unknown | 36 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2017.
All research outputs
#4,210,528
of 22,962,258 outputs
Outputs from Alzheimer's Research & Therapy
#916
of 1,238 outputs
Outputs of similar age
#75,349
of 309,400 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#21
of 28 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,238 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.